Augmentation and Combination Strategies in Antidepressants treatment of Depression
نویسنده
چکیده
منابع مشابه
Comparing augmentation with non-antidepressants over sticking to antidepressants after treatment failure in depression: a naturalistic study.
INTRODUCTION Non-response to an antidepressant monotherapy in unipolar depression is quite common. Therefore strategies for subsequent treatment steps are necessary. However, there is a lack of direct comparisons of these different strategies. In this naturalistic study we compared the outcome to different strategies after failure of the primary antidepressant treatment. METHODS Failure of pr...
متن کاملPharmacological approaches to the challenge of treatment-resistant depression
Although monoaminergic antidepressants revolutionized the treatment of Major Depressive Disorder (MDD) over a half-century ago, approximately one third of depressed patients experience treatment-resistant depression (TRD). Such patients account for a disproportionately large burden of disease, as evidenced by increased disability, cost, human suffering, and suicide. This review addresses the de...
متن کاملCombination/augmentation strategies for improving the treatment of depression
Depression is a common and debilitating condition, with considerable impact for depressed individuals and a heavy burden for society. In spite of its prevalence, depression is underrecognized and under- or inappropriately treated. In spite of the large number of antidepressants available at the present time, they are far from ideal and all show a similar slow, and frequently, incomplete respons...
متن کاملOlanzapine and fluoxetine combination therapy for treatment-resistant depression: review of efficacy, safety, and study design issues
Treatment-resistant depression (TRD) is a common occurrence in clinical practice. Up to 30% of patients with major depression do not respond to conventional antidepressant treatment, while a significantly greater number of patients experience only partial symptom reduction. Numerous strategies may be applied by the practicing clinician to overcome limitations in the effectiveness of antidepress...
متن کاملLithium's emerging role in the treatment of refractory major depressive episodes: augmentation of antidepressants.
BACKGROUND The late onset of therapeutic response and a relatively large proportion of nonresponders to antidepressants remain major concerns in clinical practice. Therefore, there is a critical need for effective medication strategies that augment treatment with antidepressants. METHODS To review the available evidence on the use of lithium as an augmentation strategy to treat depressive epi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009